In multi-component reactions (MCRs), all the required reactants are simultaneously incorporated into one pot to produce the products in a single step. Therefore, the probability of side product formation is higher in these reactions, and thus the development of an efficient catalyst is a central part of achieving ideal MCR goals successfully. Hence, efforts have been made to develop an active catalyst towards achieving high yields in MCR reactions. Catalyst based on chemical entities (piperidine, trimethylamine, TEBA, L-proline and nanoparticles of metal/metal oxides) have toxic effects, prolonged reaction time, hectic separation, low yields and the inability of catalyst reuse during MCRs. Thus we have utilized green approach to synthesize 4H-pyrans via one-pot multicomponent reaction using A cytochrome c-urea functionalized dipeptide conjugate. Our fabricated catalyst provides an efficient hydrogen bonding framework for the MCRs. We have also used ILs coated carbon quantum dots as an efficient sensor for the active ester rearrangement reactions.